When Arsenal and Liverpool played out a scoreless draw at the Emirates in August, Arsenal were without both of their first choice center backs. Now, in a role reversal that literally no one asked for, it will be Liverpool severely lacking in their defense. The good news for Reds fans is that it appears that Kolo Toure will be in contention to play on Wednesday. Liverpool also surprised everyone on Tuesday by announcing that they had signed QPR's Steven Caulker, who had been on loan with Southampton, until the end of the season. Caulker is expected to slot into the team on Wednesday against the league leaders.
The other good news is that all of the first team players who survived the Stoke game, except Christian Benteke, got a full week to rest, with Klopp preferring to field a very young squad against Exeter City at the weekend. The likes of Clyne, Moreno, Can, Firmino, and Lallana all desperately needed a break after the punishing schedule of the last several weeks.
For Arsenal, they may be the current league leaders, but they're by no means infallible. That much was shown recently when they were destroyed by Southampton in the league. Liverpool fans will be hoping that their team's pattern so far under Klopp of winning the most difficult games on the schedule will continue on Wednesday. After the second humbling and embarrassing defeat to West Ham in the league this season, the team could really use a morale-boosting victory.
If they are to win, though, it will have to be without Daniel Sturridge, who is still not fit, as well as Divock Origi and midfield maestro Philippe Coutinho. On the other hand, captain Jordan Henderson may be available, as well as Jordon Ibe, both of whom have been training with the first team this week.
Arsenal will still be without Alexis Sanchez, who is recovering from a hamstring injury, as well as Tomas Rosicky, Danny Welbeck, Jack Wilshere, Francis Coquelin and Santi Cazorla. David Ospina faces a late fitness test, but Joel Campbell may be back in contention for the Gunners, along with Mathieu Flamini and the red hot Mezut Özil.
Clyne/ Toure/ Caulker/ Moreno
Milner/ Firmino/ Lallana
Jorda(o)ns Henderson and Ibe may get starts depending on their fitness levels. If one or both are ready to start, it could lead to Klopp choosing to leave Benteke on the bench and using Firmino as a striker as he did in the first leg league cup victory against Stoke.
Kickoff is set for 8:00PM GMT/3:00PM EST Wednesday. Television coverage will be on BT Sport 1 in the UK and NBC Sports Network for the US. Elsewhere, Fox Sports 4 Australia in Australia, Sportsnet West, Sportsnet Ontario, Sportsnet East, Sportsnet Pacific, Sportsnet World Now in Canada, Star Sports HD 1 Asia in India, SuperSport 3 Africa in Kenya, Astro SuperSport 3 in Malaysia, and 102 (hd) mio Stadium in Singapore are carrying the match. You can find other listings at LiveSoccerTV. Online streaming is also available with NBC Sports Extra in the US. For Online radio, fans worldwide can check out LFCTV GO and TalkSport Radio World.
We'll be keeping you updated with all the buildup to the game, including team news as it's released, our live matchday thread and post-match recaps from The Liverpool Offside staff. If you want to join the discussion, sign up for an SB Nation account to have your say on all the action as it happens.