The most obvious thing Rafa will do is start the players who did not participate in mid-week international friendlies which was Carragher, Arbeloa, Pennant, and apparently Sissoko. As far as I know, Momo did not play for Mali against Burkina Faso. I can also seem him playing players who did not play the full matches for their country, which includes Kuyt, Babel, Torres, Alonso, and Finnan. And I definitely think Reina will be ready to go, he is only a keeper after all.
That leaves only one position, beside Carra at centre back, and being that both Hyypia and Agger played the full 90 for their respective countries, the younger Agger will probably be called on to start. I can't see him doing something crazy like giving Paletta the start this early in the season away from home.
What I would really love is to see is Leto start on the left, but I'm not sure if he legally can play for us yet. Also, it would be nice to have Kewell fit as well, but if he's not ready to go, there's no reason to rush him. Ultimately, I think Rafa will put the most rested, best available team regardless of the match-ups. We should be superior at all positions anyhow. Anyhow, here's how I see it:
I don't think we'll have much trouble with Sunderland, even though it is away from home, but you never know. As long as we keep up our aura of not undermining our opponents as we have this season, we should be fine. Cheers.